Hamilton Health Sciences is advancing excellence in health care through research and education in order to benefit the people and communities we serve. We take a multidisciplinary and collaborative approach which allows us to share our knowledge beyond borders and promote the adoption of best practices within Canada and internationally.
For this reason, we have become a world leader in advancing and creating new knowledge that allows us to better serve our patient community. Our state-of-the-art research facilities reflect the high caliber of our internationally renowned research teams and healthcare providers. Together, we conduct research that informs patient care by bringing evidence into practice through translation and application.
A world leader in large clinical trials and population studies, Population Health Research Institute (PHRI) is Canada’s premier cardiovascular research institute. World-class researchers conduct some of the largest studies in the world, spanning all frontiers of the globe and covering a broad spectrum of health-related issues. PHRI’s population science focus examines biological and genetic determinants, as well as social, environmental and policy factors, with an emphasis on risk factors and the prevention of heart attacks, stroke, diabetes, kidney disease and cognitive decline. PHRI has conducted more than 80 global trials and epidemiological studies in more than 1,500 centres, in 86 countries, in all inhabited continents. PHRI has the expertise and infrastructure to simultaneously conduct multiple studies—including its largest, PURE involving 400,000 combined participants, and over 20 studies involving 10,000 patients each plus numerous pilot and substudies. To this end, PHRI is fast approaching 1,000,000 enrolled participants world-wide.
Formed in 1992 with a focus on cardiovascular disease and diabetes, PHRI’s research areas have broadened to include population genomics, perioperative medicine, stroke, thrombosis, CV surgery, renal, obesity, childhood obesity, bone and trauma, neglected diseases and knowledge translation / implementation science. Over the years, PHRI has developed and honed unparalleled expertise in epidemiology and population health conducting some of the largest trials in the world.
PHRI research has led to more than 1,250 published papers in renowned medical journals, nine international regulatory approvals and numerous guideline recommendations around the world.
In 2011 PHRI was ranked as the research institute with the 7th highest impact in the world, and the highest in Canada, by the European organization, SCIMAGO.
More about PHRI's Research Themes
“Our team has helped improve the prevention and the treatment of cardiovascular diseases and diabetes worldwide.”
Dr. Yusuf is the Founder and Executive Director of the Population Health Research Institute (PHRI), Vice President of Research for Hamilton Health Sciences, a Joint Member of the Department of Clinical Epidemiology & Biostatistics, Professor of Medicine for McMaster University, Marion W. Burke Chair in Cardiovascular Disease for the Heart and Stroke Foundation of Ontario, and President Elect for the World Heart Federation.
His long list of awards and accomplishments include becoming a Fellow of the Royal Society of Canada, and recipient of the Prix Galien Research Award, the Louis and Artur Lucian Award for Research, the Paul Wood Silver Medal for Cardiology Research, the R.T. Hall Professorship for Cardiology and most recently, he was appointed Officer of the Order of Canada. He has published over 500 articles, making him one of the top cited physicians in the world and the author of many citation classics.
Dr. Yusuf’s research interests include societal, biologic and genetic determinants of population health in developing populations, and his studies involve over 86 countries in all the inhabited continents of the world.
PHRI is located in the 200,000 square foot, state-of-the-art David Braley Cardio, Vascular and Stroke Research Institute (DBCVSRI) at the Hamilton General Hospital Site. For more information about PHRI studies or its researchers please visit: www.phri.ca
Population Health Research Institute
237 Barton Street East
Hamilton, ON L8L 2X2
The primary focus of the Thrombosis & Atherosclerosis Research Institute (TaARI) is research excellence in thrombosis and atherosclerosis. TaARI’s core research programs include the Experimental Thrombosis and Atherosclerosis Program, the Clinical Thromboembolism Program, the Biometrics Group, and the Comparative Medicine Program which focuses on the translation of basic research findings into clinically relevant models prior to evaluation in humans.
Renamed in 2010 as TaARI, the institute is world-renowned with a rich history dating back to 1988 when it was established as the Henderson Research Centre, a joint initiative of McMaster University and Hamilton Health Sciences.
TaARI’s research objectives are to carry out basic, clinical, and epidemiologic research in thrombosis, atherosclerosis and cardiovascular disease, including venous thrombosis, pulmonary embolism, coronary heart disease, arrhythmias, congestive heart failure, cardiac thromboembolism, cerebrovascular disease, and peripheral vascular disease.
The scope of research is broad, extending from the basic laboratory to the bedside and beyond into the local, national and international communities.
A unique feature of TaARI is that the research is driven by clinically relevant problems which, if solved, have the potential to be translated rapidly into efficacious and cost-effective patient care or preventative strategies.
More about TaARI’s Research Themes.
Dr. Jeffrey Weitz, Executive Director
“Our research at the program goes right from basic research to animal models to clinical trials so we really can do true bench to bedside work.”
As Executive Director of TaARI and Director of TaARI’s Experimental Thrombosis and Atherosclerosis Program, Dr. Weitz is responsible for a mix of administrative and research duties.
In terms of research, Dr. Weitz focuses on clotting problems which can lead to heart disease and stroke, the number one cause of death and morbidity in Canada and worldwide.
While research is a large portion of his work, Dr. Weitz also enjoys teaching graduate students, medical students and residents, and sees patients with complex clotting disorders on a regular basis.
The Thrombosis & Atherosclerosis Research Institute (TaARI) is located in the 200,000 square foot, state-of-the-art David Braley Cardio, Vascular and Stroke Research Institute (DBCVRSI) at the Hamilton General Hospital site.
For more information about TaARI studies or its researchers, please visit: www.taari.ca.
The Thrombosis & Atherosclerosis Research Institute (TaARI)
Department of Medicine, McMaster University
David Braley Research Institute C5-121
237 Barton Street East
Tel: 905-521-2100, ext. 40762
The Offord Centre (originally the Canadian Centre for the Study of Children at Risk) was established by Dr. Dan Offord in 1992.
The Offord Centre’s primary focus is to better understand the causes and consequences of children’s mental health problems from a population health perspective. Combining expertise in child psychiatry, psychology, social work, nursing, epidemiology, pediatrics and policy development, the Offord Centre encourages innovation and cross-disciplinary collaboration.
Working in close affiliation with two world-class medical communities, McMaster Children’s Hospital and the Faculty of Health Sciences at McMaster University, creates an even greater diversity of skills. The affiliation provides access to a multitude of other related disciplines (health economics, genetics, neuro-development research and more), as well as an ongoing connection to the practical realities of children’s mental health issues through the many programs and clinics of the Hospital’s Child and Youth Mental Health Program.
The team also enjoys the strong support and involvement of groups and institutions including school boards, parent organizations, Children’s Aid Societies and children’s mental health centres.
Research conducted at the Offord Centre has had an important impact in Ontario, in Canada, and internationally. It is commonly stated that one in five children in Canada have a mental health challenge. That statistic comes from the Offord Centre’s 1983 landmark study, The Ontario Child Health Study, one of the most important population-based studies on children’s mental health conducted anywhere in the last 30 years.
From that study, it was also determined that one in ten children has a severe disability, medical or otherwise, that limits his or her development; one in twenty has multiple challenges interfering with successful transition at school entry; and that between 50% and 80% of all adult mental health problems begin in childhood. These findings have had an enormous impact on public policy in Canada.
In 2013, the Offord Centre received funding to conduct a sequel to its ground-breaking Ontario Child Health Study. The 2014 Ontario Child Health Study will be done in collaboration with Statistics Canada and will include more than 13,500 Ontario children, ages 4 to 17. The Centre has also had a major impact on other areas of research, including family violence and work in autism which has facilitated the implementation of early intervention and the use of clinical micro-arrays as a first line genetic test.
"Members of the Offord Centre are committed to understanding and reducing health inequalities among children and youth. We believe that an important opportunity to achieve these objectives lies in conducting research that will inform policies, programs and practices of the institutions critical to our civic society and embedded in our education, health and child and youth service systems."
- Dr. Michael Boyle, Director
Dr. Boyle was named Director of the Offord Centre for Child studies in late 2013. Over his career, he has made important contributions to child health, from influencing government health policy to increasing the efficiency and validity of epidemiological research on children. Dr. Boyle is best known for the Ontario Child Health Study (OCHS), the first large-scale observational study of children and families ever conducted in Canada. This Ontario-wide epidemiological study set the methodological standards for conducting studies in the community, and has influenced the allocation of resources and health services by highlighting the scale of mental health problems in children. Follow-up studies to the OCHS were conducted in 1987 and 2000. A more comprehensive sequel, the 2014 Ontario Child Health Study, has been funded and will begin in fall 2014. In 2009, Dr. Boyle was awarded the Michael Smith Prize for Health Research by CIHR for his of innovation, creativity, leadership and dedication in health research.
The Offord Centre for Child Studies is located at McMaster Innovation Park – Suite 201A, at 175 Longwood Road South in Hamilton, Ontario. We are a few minutes away from McMaster University’s main campus.
For more information about Offord studies or its researchers, please visit www.offordcentre.com.
Offord Centre for Child Studies
McMaster Innovation Park
175 Longwood Road S., Suite 201A
Hamilton, ON L8P 0A1
The Geriatric Education and Research in Aging Sciences (GERAS) Centre is uniquely positioned to be a leader in successful aging in Hamilton, Ontario. In partnership with St. Peter’s Hospital and McMaster University, this centre is strong in its collaborative team-based care delivery with access to leading geriatric medicine specialists and psychiatrists, interprofessional teams, and a concentrated ambulatory practice.
The GERAS Centre is committed to educating and empowering seniors to regain and retain independence and to manage their health through active participation in their care. These new models of care engage family members and build capacity for support within the community. The experts at St. Peter’s are also dedicated to advancing health care education for the present and next generation of health care professionals. Through innovative research the GERAS Centre will close the gap between knowing and doing to contribute to improved quality of life for seniors.
The GERAS Centre is focused on providing exemplary care in geriatrics through a rapid learning health system approach, which acknowledges the fundamental linkage between research, practice, and education, and uses evidence-based strategies to provide successful point-of-care improvements. Research and education is focused in three overarching themes: Frailty, Falls & Fractures, Dementia & Delirium, and End of Life Care.
The core themes serve as the platform for the GERAS Centre’s strategic directives:
Research – Improve quality of living for seniors with chronic diseases through innovative research.
Interprofessional Education – Advance interprofessional education for leaners and health professionals in the care of seniors and their families.
Seniors and Families – Develop and evaluate health promotion strategies
“The GERAS Centre represents the respect our team has for older adults and the commitment we have to providing exemplary care in geriatrics.”
Dr. Papaioannou is the Scientific Director of the GERAS Centre, responsible for leading a cross-disciplinary team with expertise in knowledge translation,
epidemiology and medical sciences. She is also a Professor of Medicine at McMaster University and a Geriatric Medicine Specialist at Hamilton Health Sciences – St. Peter’s Hospital.
As the Canadian Institutes of Health (CIHR) and Eli-Lilly Research Chair, Dr. Papaioannou does research focused on the impact of fractures, falls and frailty. She has made significant contributions to the study of osteoporosis, holding roles such as Co-Chair of the Ministry of Health and Long Term Care Strategy for Ontario, lead investigator for the Long-term Care Osteoporosis Strategy and Co-Director Alexctor of the Hamilton Canadian Multi-Centre Osteoporosis Study (CaMos).
The GERAS Centre is located in the Juravinski Research Centre at the St. Peter’s Hospital site.
For more information about the GERAS Centre, please visit:
Hamilton Health Sciences
St. Peter’s Hospital site,
88 Maplewood Avenue, Hamilton ON, L8M 1W9
Tel: 905-521-2100, ext. 12435
The Clinical Research Laboratory and Biobank [CRLB] is a state-of-the-art research facility which provides comprehensive Central Laboratory services to support global clinical studies and innovative research.
The CRLB started at the Hamilton General Hospital some twenty years ago and grew to become a world-class facility. Significant expansions in the early 1990s and again more recently
have established the CRLB as a Core Laboratory for many of Hamilton Health Sciences research studies, including the PHRI whose needs instigated the expansions.
The CRLB's biobank provides high-quality storage facilities for the many biological samples being collected. Presently, there are more than 3 million samples stored in nitrogen vapour at -160 to -190°C.
The facility has the capacity to accommodate 100 large storage tanks, each holding approximately 80,000 vials. Samples in the Biobank are linked to relevant clinical information relating to diabetes, obesity, cardiovascular disease, hypertension, stroke, kidney disease, fractures and cancer.
The CRLB is Canada’s largest biobank with over 3 million samples.
The CRLB has expertise in cryospecimen shipment (utilizing unique vapour shippers), receiving, storage, and analysis of very large numbers of samples from more than 60 countries. Most recently, the CRLB has expanded its analytical capabilities to accommodate large numbers of specimens and the strictest levels of quality control.
In addition to supporting the work of Hamilton Health Sciences researchers, the CRLB also conducts its own investigations which are funded by peer-reviewed grants from Canada, the US, and the European Community.
The CRLB continues to grow in partnership with the pharmaceutical industry, diagnostic companies, and as a specialized laboratory for research contract organizations and commercial laboratories.
More about CRLB's Research Themes.
Dr. Matthew J. McQueen, Director
Dr. McQueen is the Director for the CRCTL and Hamilton General Hospital and McMaster University Lipid Research Clinic.
His research focus includes cardiovascular disease with particular emphasis on lipids, lipoproteins and apolipoproteins, as well as the role of biomarkers in the prediction, diagnosis and management of myocardial ischemia.
In the clinical setting, Dr. McQueen focuses on the use of lifestyle and pharmacological interventions in the prevention and management of cardiovascular disease.
The CRLB is located at 237 Barton Street East, Hamilton, and is part of the Hamilton General site of Hamilton Health Sciences.
For more information about CRLB studies or its researchers, please visit http://www.crlblab.ca
Hamilton General Hospital
237 Barton Street East
Tel: 905-527-4322 x44259
The Farncombe Family Digestive Health Research Institute (FFDHRI) is an integrated group of clinical and basic scientists dedicated to understanding the impact of commensal and pathogenic microbes, diet and stress on digestive diseases across the life span, with particular emphasis on the role of the intestinal microbiome. FFDHRI is focused on developing new strategies for diagnosis, treatment and prevention of inflammatory and functional intestinal diseases what include Crohn’s disease, ulcerative colitis, gluten-sensitivity and Irritable Bowel Syndrome and its psychiatric co-morbidity. Given the high prevalences of these disorders, FFDHRI's research will have significant societal benefits.
The McMaster Brain-Body Institute at St. Joseph's Healthcare Hamilton (BBI) is a joint research initiative between St. Joseph's Healthcare, Hamilton Health Sciences and McMaster University, and was created to advance the understanding of relations between the brain, the nervous system and bodily disorders.
Clinical and basic scientists in this multidisciplinary Institute study the interaction and impact of environmental factors, including stress, early life experiences, and early microbial exposure on the brain and nervous system.
The mission of the Immunology Research Centre is to create and implement approaches utilizing the delivery of genes as therapeutic agents in the treatment of human and animal disease. The Centre is focused on developing novel cures for cancer, inflammatory diseases and infectious diseases using state-of-the-art gene transfer technology coupled with the most recent information derived from the application of genomics.
The McMaster Transfusion Research Program (MTRP) is a joint partnership between the Canadian Blood Services (CBS) and McMaster University, Faculty of Health Sciences. MTRP is dedicated to the advancement of innovative evidence-based diagnostic, clinical, and therapeutic practices in Transfusion Medicine. Their ultimate goal is to provide scientific evidence that will inform transfusion practice and enhance the safety of blood recipients.