Research with Impact-Dr. Martin O’Donnell

A series of articles has been created by HHS Research which shine the spotlight on studies published in 2014 with an HHS Researcher as lead author. Each piece features a study published in a journal with an Impact Factor greater than 10 and provides information about the author and about the research they lead. If their work strikes a cord with you, Tweet us at @HamHealthSc and include #HHSResearch.

Dr. Martin O’Donnell MB MRCPI is Associate Clinical Professor, Divisions of General Internal Medicine and Hematology and Thromboembolism, Department of Medicine at McMaster University. His research interests include: research in evidence-based medicine and vascular disease, particularly in the areas of stroke and venous thrombosis.  

ODONNELLMARTIN March 2009 0903-292           


O’Donnell, M., Mente, A., Koon, T., Yusuf, S. (2014). Urinary sodium and potassium excretion, mortality and cardiovascular events, New England Journal of Medicine, 371, 612-632.

Background of study: The optimal range of sodium intake for cardiovascular health is controversial.

Conclusions: In this study, in which sodium intake was estimated based on measured urinary excretion, an estimated sodium intake between 3 g per day and 6 g per day was associated with a lower risk of death and cardiovascular events than was either a higher or lower estimated level of intake. As compared with estimated potassium excretion that was less than 1.50 g per day, higher potassium excretion was associated with a lower risk of death and cardiovascular events.